Invitro Olive

International Journal of Pharmaceutics 166 (1998) 123 133 In vitro evaluation of the antioxidant inhering action and bio membrane interaction of the plant phenols oleuropein and hydroxytyrosol Antonella Saija a,*, Domenico Trombetta a, Antonio Tomaino a, Rossella Lo Cascio a, Pietro Princi b, Nicola Uccella c, Francesco Bonina d, Francesco Castelli e a discussion section Farmaco-Biologico, School of Pharmacy, Uni6ersity of Messina, 98168 Messina, Italy b C.I.I.F.T., Uni6ersity of Messina, 98168 Messina, Italy c CIRASAIA, Uni6ersity of Calabria, Calabria, Italy d Department of pharmaceutic Sciences, Uni6ersity of Catania, Catania, Italy e Department of chemical Sciences, Uni6ersity of Catania, Catania, Italy Received 4 appalling 1997; received in revise form 18 celestial latitude 1997; accepted 18 December 1997 Abstract Oleuropein and hydroxytyrosol, both phenolic compounds contained in olives and olive oil, argon known to occupy several biological properties, m any of which may be related, part at least, to their antioxidant and free mathematical group-scavenger ability.

Hence, together with their scavenging action against the stable 1,1-diphenyl-2-picrylhydrazyl radical (DPPH test), we have investigated the antioxidative force out of oleuropein and hydroxytyrosol in a place system consisting of dipalmitoylphosphatidylcholine/linoleic acid unilamellar vesicles (DPPC/LA LUVs) and a water-soluble azo compound as a free radical source (LPLUV test). The results obtained were also interpreted in the light of biophenol interactions, examine by differential scanning calor imetry (DSC), with dimyristoylphosphatidylch! oline (DMPC) vesicles as a biological membrane model. Our results obtained in the DPPH and LP LUV tests con?rm the good scavenger occupation and antioxidant effect of oleuropein and hydroxytyrosol. However, while both compounds exhibit comparable intensity in the DPPH test (hydroxytyrosol being slightly more alert than oleuropein), oleuropein seems, in the LPLUV test, a...If you want to get a full essay, enjoin it on our website: OrderCustomPaper.com

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