All of the factors shown above to affect T cells in addition have a deleterious affect on B cells, which eventually differentiate into plasma cells. These plasma cells produce antibodies, which own a great amount of variability in format to recognize a large array of antigens. A study by Kirman et al (1998) showed an increase in the number of apoptotic B cells within the bone marrow. Though a direct federation between B cell apoptotic death and T cell malfunction has not been shown, the relationship between the T cells and the hypermutability of the changeable region of antibodies is known to exist.
T cells which have venerable and have reached beyond a real point within the cell cycle are unable to interact properly with B cells, leading to a decline in the variability of certain antibodies. The IgM is one example. IgM is one of the first immunoglobulins to defend whenever the immune cascade is initiated and its numbers seem to be without delay affected by the suppressed interactivity of the B cell and the T cell.
Moriguchi, S. (1998). the role of vitamin E in T-cell differentiation and the decrease of cellular immunity with aging. BioFactors., Vol. 7, no. 1-2,pp. 77-86
Recent research has indicated that the immune systems of aged people undergo characteristic changes, generally in the counselling of decreased immune competence. As the research presented in this idea reveals, aging affects many aspects of the immune process, and since the immune system interacts with any system of the body it becomes important to have a well developed understanding of the mechanisms related to the breakdown of this system in the later years of life. Clarification of these mechanisms can lead to the victimisation of new ways of combating disease, preventing life threatening infections and ultimately providing a better quality of life during an individuals older years.
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